Gilvocarcins, new antitumor antibiotics. 2. Structural elucidation.
نویسندگان
چکیده
Gilvocarcin V(1), C27H28O9, m.p. 264 approximately 267 degrees C (dec.), and gilvocarcin M(2), C26H26O9, m.p. 245 approximately 248 degrees C (dec.), are new antitumor antibiotics produced by Streptomyces gilvotanareus. The structure of gilvocarcins has been determined by chemical degradation, nmr and mass spectra. They have a benzonaphtopyran-one system, to which the furanose moiety is linked through a C-C glycosyl bond.
منابع مشابه
Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E.
Very recently, ToMITA and coworkers' 2) have reported the fermentation, isolation and structure elucidation of gilvocarcins V (1) and M (2). They note that I was previously described under the name of toromycin by HORII et al.3) although the structure of toromycin was not elucidated. Recently we have isolated 1 and 2 and a related compound gilvocarcin E (3) from a culture of Streptomyces anandi...
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Gilvocarcin V and gilvocarcin M, a group of antitumor antibiotics with a novel skeleton, were discovered in culture broths of Actinomycete DO-38. The producing organism, subsequently determined to be a new species and named Streptomyces gilvotanareus (NRRL 11382). Gilvocarcin V and M were isolated by ethyl acetate extraction and chromatography on silica gel. The antibiotics are active against G...
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عنوان ژورنال:
- The Journal of antibiotics
دوره 34 3 شماره
صفحات -
تاریخ انتشار 1981